The heat sensitive materials drying and solvent extracting from the polymers structures, the bio components and inorganic are the main consideration of pharmaceutical industry, food, medicine, etc. Freeze-drying is a widely used process for water extracting from biomaterials and inorganic materials, also for drying and improving the stability of rare metals, ceramics, inorganic sensitive materials and various pharmaceutical products including viruses, vaccines, proteins, peptides, or colloidal carriers: liposomes, nanoparticles, nanoemulsions. This process is relatively slow and expensive, it especially applies only to high added value products. The freeze-drying cycle can be divided into three steps: freezing (solidification), primary drying (ice sublimation) and secondary drying (desorption of unfrozen water). At the first step, the liquid suspension is cooled, and ice crystals of pure water forms. At the second, sublimation of ice from the frozen product and at the end evaporation of the sample residual moisture occurs