In recent years, a new generation of biomaterial-based products has emerged, focusing on natural tissue regeneration rather than short-term cosmetic correction.

Formulated using calcium hydroxyapatite (CaHA) and poly-L-lactic acid (PLLA) particles, these products not only provide immediate volumization but also stimulate the skin’s natural collagen production, enabling gradual and sustained tissue regeneration. Developed using domestic technological expertise, the two fillers offer long-lasting results, progressive effects, and high safety, presenting a new outlook for the aesthetic medicine and regenerative skincare industries.

The growing demand for safe, durable, and natural-looking skin rejuvenation methods has pushed the aesthetics industry into a new phase. While patients once sought fillers mainly for short-term wrinkle correction, they now increasingly prefer solutions that work biologically within the body, encouraging the skin to regenerate itself. In this context, nanotechnology and biotechnology have become central to the design of next-generation smart fillers.

By developing InShape Radiance Plus and InShape Scalp, Nanodaru Pajuhan Pardis has introduced fully Iranian products that can compete with leading international brands, each activating rejuvenation through a distinct biological mechanism.

InShape Radiance Plus is a dermal filler based on nanoscale calcium hydroxyapatite (CaHA) particles, designed to deliver a dual-mode effect. The biocompatible CaHA particles, precisely engineered in the 25–45 micron range, form a microscopic scaffold within the deeper layers of the skin after injection

The first phase of action provides immediate volumization, effectively correcting moderate to deep wrinkles such as nasolabial folds, jawline creases, and dorsal hand depressions. This instant result is particularly appealing to patients, as visible improvement is observed on the day of treatment.

The second and more critical phase involves gradual stimulation of collagen production. Over the following months, CaHA particles activate fibroblasts, prompting the body to rebuild its own tissue from within. This leads to firmer, smoother, and more youthful skin that develops naturally over time. Specialists report that the effects of this filler can last more than 18 months, with its two-stage mechanism making it a preferred option for long-term rejuvenation.

The product is supplied in pre-filled syringes and includes 0.3% lidocaine to reduce injection discomfort. Its gel matrix contains glycerin and sodium carboxymethyl cellulose, enhancing stability and uniform particle distribution within the tissue. Combined with high biocompatibility, these features make InShape Radiance Plus suitable for sensitive facial and hand areas.

In contrast to conventional fillers, InShape Scalp employs poly-L-lactic acid (PLLA) microspheres, a biodegradable polymer widely used in medicine as a collagen stimulator. Unlike hyaluronic acid fillers, InShape Scalp does not create significant volume immediately after injection. Instead, it gradually forms a regenerative scaffold beneath the skin over several months.

Once injected, PLLA microspheres activate fibroblasts and enhance the production of type I and type III collagen, restoring lost volume in areas such as deep wrinkles, sunken cheeks, jawline folds, scars, and even lipoatrophy caused by subcutaneous fat loss. Clinically, PLLA-based fillers have demonstrated strong effectiveness in treating HIV-associated lipoatrophy and are recognized internationally as standard solutions for long-term volume restoration.

The formulation includes sodium carboxymethyl cellulose and mannitol, which facilitate particle activation and distribution. The **durability of treatment effects—reported to last up to two years—**significantly exceeds that of conventional gel fillers, positioning InShape Scalp as a key option not only in aesthetics but also in regenerative and reconstructive therapies.

A notable aspect of both products is that their entire production cycle, from formulation to quality control, is carried out domestically. This technological independence offers several advantages: reducing foreign currency outflow in a market dominated by expensive imported fillers; providing physicians and patients with safer, more affordable options; and building national capacity in biomaterials, tissue engineering, and nanomedicine.

The production of these fillers requires advanced manufacturing lines, specialized laboratory equipment, and skilled research teams, underscoring the critical role of knowledge-based companies in advancing this sector.

Experts note that the combined use of InShape Radiance Plus and InShape Scalp can address a wide range of aesthetic and therapeutic needs. Radiance Plus is ideal for immediate correction with gradual regeneration, while Scalp is suited for deep tissue restoration, lifting, treatment of severe wrinkles, and correction of fat loss. In some treatment protocols, the complementary use of both products has yielded highly natural and long-lasting outcomes.

Dermatology specialists also emphasize how these fillers differ fundamentally from older gel-based options. Traditional fillers, such as hyaluronic acid, rely mainly on water absorption to create volume and typically last less than a year. In contrast, CaHA- and PLLA-based biocompatible fillers work by activating the body’s own cells, resulting in a more natural appearance and extended longevity.

Overall, the introduction of InShape Radiance Plus and InShape Scalp highlights the growing capabilities of Iranian nanotechnology and biotechnology in the aesthetic medicine sector. Beyond meeting domestic clinical needs, these innovations have the potential to support Iran’s expanded presence in the global skin rejuvenation market, where demand for biological and natural treatment approaches continues to rise.