The research aims to investigate the specific loss potential of nanoparticles prepared for the treatment of cancerous masses using magnetic transduction method.
“In this work, magnetite nanoparticles as well as magnetite nanoparticles replaced with zinc and samarium were made using co-precipitation method. The nanoparticles were coated with citric acid and pluronic copolymer F127, in which acceptable stability was observed for ferroflux for a long time (several weeks),” Morteza Mozaffari, associate professor of University of Isfahan, said, “despite their large size, nanoparticles are well dispersed in the fluid and samples with low concentrations showed very good dissipation.”
These nanoparticles can be used for targeted drug delivery and to improve MRI and MPI imaging. Based on the data obtained from various experiments, despite the large size of nanoparticles dispersed in the solution and the large magnetic interaction between them, ferroflux remained floating in an aqueous medium (pH 5.5) for a long time and showed good stability. The experiments showed that these samples were very good options for use in the treatment of cancerous masses by magnetic resonance imaging.
Referring to the innovative features of the project, Mozaffari said: "Replacement of samarium ions in iron oxide nanoparticles for extraterrestrial applications, which is less common than replacement of other rare earth ions, is coated with F127, citric and pluronic acid, which is very biocompatible and commonly used in medicine." "They are suitable, and the very good stability of the nanoparticle market, despite their large size, is a feature of this research."
The results of the project were published as an article in the journal of Scientific Reports entitling “Heat dissipation in Sm3+ and Zn2+ co-substitued magnetite nanoparticles coated with citric acid and pluronic F127 for hyperthermia application.”
June 21, 2022
Scientific
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